CATH Domain 3rh0A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2300	Response regulator

Domain Context

CATH Clusters

Superfamily	3.40.50.2300
Functional Family

Enzyme Information

2.8.4.2

Arsenate-mycothiol transferase.

based on mapping to UniProt P0DKS7

Arsenate + mycothiol = arseno-mycothiol + H(2)O.

-!- Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. -!- The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. -!- Finally, a second mycothiol recycles mycoredoxin and forms mycothione.

UniProtKB Entries (1)

P0DKS7

ARSC2_CORGL

Corynebacterium glutamicum ATCC 13032

Arsenate-mycothiol transferase ArsC2

PDB Structure

PDB	3RH0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Corynebacterium glutamicum survives arsenic stress with arsenate reductases coupled to two distinct redox mechanisms Villadangos, A.F., Van Belle, K., Wahni, K., Dufe, T.V., Freitas, S., Nur, H., De Galan, S., Gil, J.A., Collet, J.F., Mateos, L.M., Messens, J. Mol.Microbiol.