CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Protein argonaute-2

Enzyme Information

3.1.26.n2
Argonaute-2.
based on mapping to UniProt Q9UKV8
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).

UniProtKB Entries (1)

Q9UKV8
AGO2_HUMAN
Homo sapiens
Protein argonaute-2

PDB Structure

PDB 3QX8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Frank, F., Fabian, M.R., Stepinski, J., Jemielity, J., Darzynkiewicz, E., Sonenberg, N., Nagar, B.
Embo Rep.