CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Deoxycytidine kinase

Enzyme Information

2.7.1.74
Deoxycytidine kinase.
based on mapping to UniProt P27707
NTP + deoxycytidine = NDP + dCMP.
-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

UniProtKB Entries (1)

P27707
DCK_HUMAN
Homo sapiens
Deoxycytidine kinase

PDB Structure

PDB 3QEN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Hazra, S., Szewczak, A., Ort, S., Konrad, M., Lavie, A.
Biochemistry