CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.176
UDP-N-acetylglucosamine kinase.
based on mapping to UniProt Q54944
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D- glucosamine 3'-phosphate.
-!- Toxic component of a toxin-antitoxin (TA) module. -!- The phosphorylation of UDP-N-acetyl-alpha-D-glucosamine results in the inhibition of EC 2.5.1.7, which is then blocked. -!- Phosphorylation is inhibited by cognate epsilon antitoxin. -!- Formerly EC 2.7.1.n7.

UniProtKB Entries (1)

Q54944
ZTOX_STRPY
Streptococcus pyogenes
Toxin zeta

PDB Structure

PDB 3Q8X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
Mutschler, H., Gebhardt, M., Shoeman, R.L., Meinhart, A.
Plos Biol.