CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Pyridoxine biosynthesis protein PDX1

Enzyme Information

4.3.3.6
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
based on mapping to UniProt Q03148
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate.
-!- The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. -!- The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. -!- The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.

UniProtKB Entries (1)

Q03148
SNZ1_YEAST
Saccharomyces cerevisiae S288C
Pyridoxal 5'-phosphate synthase subunit SNZ1

PDB Structure

PDB 3O07
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1
Zhang, X., Teng, Y.B., Liu, J.P., He, Y.X., Zhou, K., Chen, Y., Zhou, C.Z.
Biochem.J.