CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Uridine monophosphate synthetase

Enzyme Information

2.4.2.10
Orotate phosphoribosyltransferase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
4.1.1.23
Orotidine-5'-phosphate decarboxylase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate = UMP + CO(2).
-!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.

UniProtKB Entries (1)

P11172
UMPS_HUMAN
Homo sapiens
Uridine 5'-monophosphate synthase

PDB Structure

PDB 3MO7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
Lewis, M., Meza-Avina, M.E., Wei, L., Crandall, I.E., Bello, A.M., Poduch, E., Liu, Y., Paige, C.J., Kain, K.C., Pai, E.F., Kotra, L.P.
J.Med.Chem.