CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Deoxycytidine kinase

Enzyme Information

2.7.1.74
Deoxycytidine kinase.
based on mapping to UniProt P27707
NTP + deoxycytidine = NDP + dCMP.
-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

UniProtKB Entries (1)

P27707
DCK_HUMAN
Homo sapiens
Deoxycytidine kinase

PDB Structure

PDB 3MJR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues.
Hazra, S., Konrad, M., Lavie, A.
J.Med.Chem.