CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Dihydroorotate dehydrogenase (quinone), mitochondrial

Enzyme Information
Dihydroorotate dehydrogenase (quinone).
based on mapping to UniProt Q02127
(S)-dihydroorotate + a quinone = orotate + a quinol.
-!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC, NAD(+) (EC or NADP(+) (EC as electron acceptor. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Dihydroorotate dehydrogenase (quinone), mitochondrial

PDB Structure

External Links
Primary Citation
Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.
McLean, L.R., Zhang, Y., Degnen, W., Peppard, J., Cabel, D., Zou, C., Tsay, J.T., Subramaniam, A., Vaz, R.J., Li, Y.