CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family 4-hydroxy-tetrahydrodipicolinate reductase

Enzyme Information

1.17.1.8
4-hydroxy-tetrahydrodipicolinate reductase.
based on mapping to UniProt Q6G2G3
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.
-!- Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought. -!- Formerly EC 1.3.1.26.

UniProtKB Entries (1)

Q6G2G3
DAPB_BARHE
Bartonella henselae str. Houston-1
4-hydroxy-tetrahydrodipicolinate reductase

PDB Structure

PDB 3IJP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 angstrom resolution.
Cala, A.R., Nadeau, M.T., Abendroth, J., Staker, B.L., Reers, A.R., Weatherhead, A.W., Dobson, R.C., Myler, P.J., Hudson, A.O.
Acta Crystallogr F Struct Biol Commun