CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt Q27686
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

Q27686
KPYK_LEIME
Leishmania mexicana
Pyruvate kinase

PDB Structure

PDB 3HQP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
Morgan, H.P., McNae, I.W., Nowicki, M.W., Hannaert, V., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
J.Biol.Chem.