CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9RT63
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9RT63
RECDL_DEIRA
Deinococcus radiodurans R1
ATP-dependent RecD-like DNA helicase

PDB Structure

PDB 3GPL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic basis of 5'-3' translocation in SF1B helicases.
Saikrishnan, K., Powell, B., Cook, N.J., Webb, M.R., Wigley, D.B.
Cell(Cambridge,Mass.)