CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Dihydroorotate dehydrogenase (quinone), mitochondrial

Enzyme Information

1.3.5.2
Dihydroorotate dehydrogenase (quinone).
based on mapping to UniProt Q02127
(S)-dihydroorotate + a quinone = orotate + a quinol.
-!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- Formerly EC 1.3.99.11.

UniProtKB Entries (1)

Q02127
PYRD_HUMAN
Homo sapiens
Dihydroorotate dehydrogenase (quinone), mitochondrial

PDB Structure

PDB 3F1Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
Davies, M., Heikkila, T., McConkey, G.A., Fishwick, C.W.G., Parsons, M.R., Johnson, A.P.
J.Med.Chem.