CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase 2

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt Q12390
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

Q12390
GST2_YEAST
Saccharomyces cerevisiae S288C
Glutathione S-transferase 2

PDB Structure

PDB 3ERG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Ma, X.X., Jiang, Y.L., He, Y.X., Bao, R., Chen, Y.X., Zhou, C.Z.
Embo Rep.