CATH Domain 3eiqD01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Eukaryotic initiation factor 4A-II

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt P60842

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (2)

Q61823	PDCD4_MOUSE Mus musculus Programmed cell death protein 4
P60842	IF4A1_HUMAN Homo sapiens Eukaryotic initiation factor 4A-I

PDB Structure

PDB	3EIQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for translational inhibition by the tumour suppressor Pdcd4 Loh, P.G., Yang, H.S., Walsh, M.A., Wang, Q., Wang, X., Cheng, Z., Liu, D., Song, H. Embo J.