CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Eukaryotic initiation factor 4A-II |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt P60842
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
UniProtKB Entries (2)
| Q61823 |
PDCD4_MOUSE
Mus musculus
Programmed cell death protein 4
|
| P60842 |
IF4A1_HUMAN
Homo sapiens
Eukaryotic initiation factor 4A-I
|
PDB Structure
| PDB | 3EIQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for translational inhibition by the tumour suppressor Pdcd4
Embo J.
|