CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00519
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00519
ABL1_HUMAN
Homo sapiens
Tyrosine-protein kinase ABL1

PDB Structure

PDB 3EGU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
Palencia, A., Camara-Artigas, A., Pisabarro, M.T., Martinez, J.C., Luque, I.
J.Biol.Chem.