CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P56109
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P56109
ALF_HELPY
Helicobacter pylori 26695
Fructose-bisphosphate aldolase

PDB Structure

PDB 3C4U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.
Fonvielle, M., Coincon, M., Daher, R., Desbenoit, N., Kosieradzka, K., Barilone, N., Gicquel, B., Sygusch, J., Jackson, M., Therisod, M.
Chemistry