CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Eukaryotic initiation factor 4A-II

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt Q14240
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q14240
IF4A2_HUMAN
Homo sapiens
Eukaryotic initiation factor 4A-II

PDB Structure

PDB 3BOR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Schutz, P., Karlberg, T., van den Berg, S., Collins, R., Lehtio, L., Hogbom, M., Holmberg-Schiavone, L., Tempel, W., Park, H.W., Hammarstrom, M., Moche, M., Thorsell, A.G., Schuler, H.
Plos One