CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P14618
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P14618
KPYM_HUMAN
Homo sapiens
Pyruvate kinase PKM

PDB Structure

PDB 3BJF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Christofk, H.R., Vander Heiden, M.G., Wu, N., Asara, J.M., Cantley, L.C.
Nature