CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Protein-tyrosine sulfotransferase

Enzyme Information

2.8.2.20
Protein-tyrosine sulfotransferase.
based on mapping to UniProt O60704
3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
-!- The tyrosine residues of some specific proteins of rat pheochromocytoma cells act as acceptors. -!- Formerly EC 2.8.2.n1.

UniProtKB Entries (1)

O60704
TPST2_HUMAN
Homo sapiens
Protein-tyrosine sulfotransferase 2

PDB Structure

PDB 3AP3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.
Teramoto, T., Fujikawa, Y., Kawaguchi, Y., Kurogi, K., Soejima, M., Adachi, R., Nakanishi, Y., Mishiro-Sato, E., Liu, M.C., Sakakibara, Y., Suiko, M., Kimura, M., Kakuta, Y.
Nat Commun