CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.4.25
(d)CMP kinase.
based on mapping to UniProt Q5SL35
ATP + (d)CMP = ADP + (d)CDP.
-!- The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. -!- Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalyzed in prokaryotes by EC 2.7.4.22. -!- The enzyme phosphorylates dCMP nearly as well as it does CMP.

UniProtKB Entries (1)

Q5SL35
KCY_THET8
Thermus thermophilus HB8
Cytidylate kinase

PDB Structure

PDB 3AKE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of the tertiary complex of CMP kinase with a phosphoryl group acceptor and a donor from Thermus thermophilus HB8
Mega, R., Nakagawa, N., Kuramitsu, S., Masui, R.
To be Published