CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family |
Enzyme Information
| 2.5.1.27 |
Adenylate dimethylallyltransferase (AMP-dependent).
based on mapping to UniProt Q5GHF7
Dimethylallyl diphosphate + AMP = diphosphate + N(6)- (dimethylallyl)adenosine 5'-phosphate.
-!- Involved in the biosynthesis of cytokinins in plants. -!- Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112.
|
| 2.5.1.112 |
Adenylate dimethylallyltransferase (ADP/ATP-dependent).
based on mapping to UniProt Q5GHF7
(1) Dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine diphosphate. (2) Dimethylallyl diphosphate + ATP = diphosphate + N6-(dimethylallyl)adenosine triphosphate.
-!- Involved in the biosynthesis of cytokinins in plants. -!- The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP. -!- Other isoforms, such as IPT1 from Arabidopsis thaliana and the enzyme from the common hop, Humulus lupulus, also have a lower activity with AMP (cf. EC 2.5.1.27). -!- Formerly EC 2.5.1.n4.
|
UniProtKB Entries (1)
| Q5GHF7 |
IPT_HUMLU
Humulus lupulus
Adenylate isopentenyltransferase
|
PDB Structure
| PDB | 3A8T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides
Nucleic Acids Res.
|