CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.164
O-phosphoseryl-tRNA(Sec) kinase.
based on mapping to UniProt Q58933
ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec).
-!- In archaea and eukarya selenocysteine formation is achieved by a two- step process: O-phosphoseryl-tRNA(Sec) kinase (PSTK) phosphorylates the endogenous L-seryl-tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by EC 2.9.1.2. -!- Formerly EC 2.7.1.n3.

UniProtKB Entries (1)

Q58933
PSTK_METJA
Methanocaldococcus jannaschii DSM 2661
L-seryl-tRNA(Sec) kinase

PDB Structure

PDB 3A4N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a tRNA-dependent kinase essential for selenocysteine decoding
Araiso, Y., Sherrer, R.L., Ishitani, R., Ho, J.M.L., Soll, D., Nureki, O.
Proc.Natl.Acad.Sci.USA