CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Eukaryotic initiation factor 4A-III

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P60842
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q53EL6
PDCD4_HUMAN
Homo sapiens
Programmed cell death protein 4

PDB Structure

PDB 2ZU6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the eIF4A-PDCD4 complex
Chang, J.H., Cho, Y.H., Sohn, S.Y., Choi, J.M., Kim, A., Kim, Y.C., Jang, S.K., Cho, Y.
Proc.Natl.Acad.Sci.Usa