CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Enzyme Information

5.3.1.24
Phosphoribosylanthranilate isomerase.
based on mapping to UniProt P9WMM5
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 4.2.1.20).
5.3.1.16
1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.
based on mapping to UniProt P9WMM5
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide.
-!- Involved in histidine biosynthesis.

UniProtKB Entries (1)

P9WMM5
HIS4_MYCTU
Mycobacterium tuberculosis H37Rv
Phosphoribosyl isomerase A

PDB Structure

PDB 2Y85
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bisubstrate Specificity in Histidine/Tryptophan Biosynthesis Isomerase from Mycobacterium Tuberculosis by Active Site Metamorphosis.
Due, A.V., Kuper, J., Geerlof, A., Kries, J.P., Wilmanns, M.
Proc.Natl.Acad.Sci.USA