CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family

Enzyme Information

1.17.7.3
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
based on mapping to UniProt Q72H18
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.
-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).

UniProtKB Entries (1)

Q72H18
ISPG_THET2
Thermus thermophilus HB27
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

PDB Structure

PDB 2Y0F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the E-1-Hydroxy-2-Methyl-But-2-Enyl-4-Diphosphate Synthase (Gcpe) from Thermus Thermophilus.
Rekittke, I., Nonaka, T., Wiesner, J., Demmer, U., Warkentin, E., Jomaa, H., Ermler, U.
FEBS Lett.