CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P12851
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P12851
XYLA_ACTM4
Actinoplanes missouriensis 431
Xylose isomerase

PDB Structure

PDB 2XIN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 1. Crystallography and site-directed mutagenesis of metal binding sites.
Jenkins, J., Janin, J., Rey, F., Chiadmi, M., van Tilbeurgh, H., Lasters, I., De Maeyer, M., Van Belle, D., Wodak, S.J., Lauwereys, M., Stanssens, P., Matthyssens, G., Lambeir, A.M.
Biochemistry