CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclodipeptide synthase
Functional Family

Enzyme Information

2.3.2.21
Cyclo(L-tyrosyl-L-tyrosyl) synthase.
based on mapping to UniProt P9WPF9
2 L-tyrosyl-tRNA(Tyr) = 2 tRNA(Tyr) + cyclo(L-tyrosyl-L-tyrosyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue. -!- The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl).

UniProtKB Entries (1)

P9WPF9
CDTS_MYCTU
Mycobacterium tuberculosis H37Rv
Cyclo(L-tyrosyl-L-tyrosyl) synthase

PDB Structure

PDB 2X9Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure and Mechanism of the Mycobacterium Tuberculosis Cyclodityrosine Synthetase.
Vetting, M.W., Hegde, S.S., Blanchard, J.S.
Nat.Chem.Biol.