CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Exo-beta-D-glucosaminidase

Enzyme Information

3.2.1.165
Exo-1,4-beta-D-glucosaminidase.
based on mapping to UniProt Q56F26
Hydrolysis of chitosan or chitosan oligosaccharides to remove successive D-glucosamine residues from the non-reducing termini.
-!- Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi and comprises D-glucosamine residues with a variable content of GlcNAc residues. -!- Acts specifically on chitooligosaccharides and chitosan, having maximal activity on chitotetraose, chitopentaose and their corresponding alcohols. -!- Can degrade GlcN-GlcNAc but not GlcNAc-GlcNAc.

UniProtKB Entries (1)

Q56F26
EBDG_AMYOR
Amycolatopsis orientalis
Exo-beta-D-glucosaminidase

PDB Structure

PDB 2X05
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of the Exo-Beta-D-Glucosaminidase Csxa by a Glucosamine-Configured Castanospermine and an Amino-Australine Analogue.
Pluvinage, B., Ghinet, M.G., Brzezinski, R., Boraston, A.B., Stubbs, K.A.
Org.Biomol.Chem.