CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family PTS sugar transporter subunit IIB

Enzyme Information

2.7.1.196
Protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase.
based on mapping to UniProt P69795
[Protein]-N(pi)-phospho-L-histidine + N,N'-diacetylchitobiose(Side 1) = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.

UniProtKB Entries (1)

P69791
PTQA_ECOLI
Escherichia coli K-12
PTS system N,N'-diacetylchitobiose-specific EIIA component

PDB Structure

PDB 2WY2
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of the Iiachitobose-Iibchitobiose Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia Coli Phosphotransfer System
Jung, Y.S., Cai, M., Clore, G.M.
J.Biol.Chem.