1 keywords

CATH Domain 2w3lA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Apoptosis regulator Bcl-2

Enzyme Information

UniProtKB Entries (1)

P10415
BCL2_HUMAN
Homo sapiens
Apoptosis regulator Bcl-2

PDB Structure

PDB 2W3L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Porter, J., Payne, A., De Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C.
Bioorg.Med.Chem.Lett.