CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9HM14
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9HM14
XPD_THEAC
Thermoplasma acidophilum DSM 1728
ATP-dependent DNA helicase Ta0057

PDB Structure

PDB 2VSF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Fes Cluster-Containing Nucleotide Excision Repair Helicase Xpd.
Wolski, S.C., Kuper, J., Haenzelmann, P., Truglio, J.J., Croteau, D.L., Van Houten, B., Kisker, C.
Plos Biol.