CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family 5-keto-4-deoxy-D-glucarate aldolase

Enzyme Information

4.1.2.52
4-hydroxy-2-oxoheptanedioate aldolase.
based on mapping to UniProt Q47098
4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde.
-!- The enzyme is also able to catalyze the aldol cleavage of 4-hydroxy- 2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. -!- In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. -!- The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate. -!- Formerly EC 4.1.2.n4.

UniProtKB Entries (1)

Q47098
HPCH_ECOLX
Escherichia coli
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase

PDB Structure

PDB 2V5K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Mechanism of Hpch: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia Coli.
Rea, D., Fulop, V., Bugg, T.D.H., Roper, D.I.
J.Mol.Biol.