CATH Domain 2v54A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P68693

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_VACCC

Vaccinia virus Copenhagen

Thymidylate kinase

PDB Structure

PDB	2V54
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy Caillat, C., Topalis, D., Agrofoglio, L.A., Pochet, S., Balzarini, J., Deville-Bonne, D., Meyer, P. Proc.Natl.Acad.Sci.USA