CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P46063
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P46063
RECQ1_HUMAN
Homo sapiens
ATP-dependent DNA helicase Q1

PDB Structure

PDB 2V1X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Human Recq1 Helicase Reveals a Putative Strand-Separation Pin.
Pike, A.C.W., Shrestha, B., Popuri, V., Burgess-Brown, N., Muzzolini, L., Costantini, S., Vindigni, A., Gileadi, O.
Proc.Natl.Acad.Sci.USA