CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Triosephosphate isomerase |
Enzyme Information
| 5.3.1.1 |
Triose-phosphate isomerase.
based on mapping to UniProt P04789
D-glyceraldehyde 3-phosphate = glycerone phosphate.
|
UniProtKB Entries (1)
| P04789 |
TPIS_TRYBB
Trypanosoma brucei brucei
Triosephosphate isomerase, glycosomal
|
PDB Structure
| PDB | 2V0T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.
Acta Crystallogr. D Biol. Crystallogr.
|