CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt Q9PPP5
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

Q9PPP5
KITH_UREPA
Ureaplasma parvum serovar 3 str. ATCC 700970
Thymidine kinase

PDB Structure

PDB 2UZ3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Thymidine Kinase 1 of Human and Mycoplasmic Origin
Welin, M., Kosinska, U., Mikkelsen, N.E., Carnrot, C., Zhu, C., Wang, L., Eriksson, S., Munch-Petersen, B., Eklund, H.
Proc.Natl.Acad.Sci.USA