CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P00572
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P00572
KTHY_YEAST
Saccharomyces cerevisiae S288C
Thymidylate kinase

PDB Structure

PDB 2TMK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Lavie, A., Vetter, I.R., Konrad, M., Goody, R.S., Reinstein, J., Schlichting, I.
Nat.Struct.Biol.