CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidine kinase

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt Q9WYN2
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

Q9WYN2
KITH_THEMA
Thermotoga maritima MSB8
Thymidine kinase

PDB Structure

PDB 2QPO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Segura-Pena, D., Lichter, J., Trani, M., Konrad, M., Lavie, A., Lutz, S.
Structure