CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.2.1.10
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
based on mapping to UniProt Q57843
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3- dioxopropylaldehyde phosphate.
-!- The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. -!- The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. -!- Formerly EC 4.1.2.n5.

UniProtKB Entries (1)

Q57843
ADHS_METJA
Methanocaldococcus jannaschii DSM 2661
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase

PDB Structure

PDB 2QJH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Morar, M., White, R.H., Ealick, S.E.
Biochemistry