CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like C-terminal domain
Functional Family

Enzyme Information

5.1.1.22
4-hydroxyproline betaine 2-epimerase.
based on mapping to UniProt Q0FPQ4
(1) Trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine. (2) L-proline betaine = D-proline betaine.
-!- The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyzes racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.

UniProtKB Entries (1)

Q0FPQ4
HPBD_PELBH
Salipiger bermudensis HTCC2601
4-hydroxyproline betaine 2-epimerase

PDB Structure

PDB 2PMQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Discovery of new enzymes and metabolic pathways by using structure and genome context.
Zhao, S., Kumar, R., Sakai, A., Vetting, M.W., Wood, B.M., Brown, S., Bonanno, J.B., Hillerich, B.S., Seidel, R.D., Babbitt, P.C., Almo, S.C., Sweedler, J.V., Gerlt, J.A., Cronan, J.E., Jacobson, M.P.
Nature