CATH Classification

Domain Context

CATH Clusters

Superfamily Metal-dependent hydrolases
Functional Family 5-methylthioadenosine/S-adenosylhomocysteine deaminase

Enzyme Information

3.5.4.28
S-adenosylhomocysteine deaminase.
based on mapping to UniProt Q9X034
S-adenosyl-L-homocysteine + H(2)O = S-inosyl-L-homocysteine + NH(3).
3.5.4.31
S-methyl-5'-thioadenosine deaminase.
based on mapping to UniProt Q9X034
S-methyl-5'-thioadenosine + H(2)O = S-methyl-5'-thioinosine + NH(3).
-!- The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. -!- Adenosine-5-monophosphate (AMP) and S-adenosyl-L-methionine (SAM) are not substrates. -!- Formerly EC 3.5.4.n1.

UniProtKB Entries (1)

Q9X034
MTAD_THEMA
Thermotoga maritima MSB8
5-methylthioadenosine/S-adenosylhomocysteine deaminase

PDB Structure

PDB 2PLM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based activity prediction for an enzyme of unknown function
Hermann, J.C., Marti-Arbona, R., Fedorov, A.A., Fedorov, E., Almo, S.C., Shoichet, B.K., Raushel, F.M.
Nature