CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.176
UDP-N-acetylglucosamine kinase.
based on mapping to UniProt Q97QZ1
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D- glucosamine 3'-phosphate.
-!- Toxic component of a toxin-antitoxin (TA) module. -!- The phosphorylation of UDP-N-acetyl-alpha-D-glucosamine results in the inhibition of EC 2.5.1.7, which is then blocked. -!- Phosphorylation is inhibited by cognate epsilon antitoxin. -!- Formerly EC 2.7.1.n7.

UniProtKB Entries (1)

Q97QZ2
PEZA_STRPN
Streptococcus pneumoniae TIGR4
Antitoxin PezA

PDB Structure

PDB 2P5T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular and Structural Characterization of the PezAT Chromosomal Toxin-Antitoxin System of the Human Pathogen Streptococcus pneumoniae.
Khoo, S.K., Loll, B., Chan, W.T., Shoeman, R.L., Ngoo, L., Yeo, C.C., Meinhart, A.
J.Biol.Chem.