CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidine kinase

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P04183
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P04183
KITH_HUMAN
Homo sapiens
Thymidine kinase, cytosolic

PDB Structure

PDB 2ORV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
Segura-Pena, D., Lutz, S., Monnerjahn, C., Konrad, M., Lavie, A.
J.Mol.Biol.