CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P08631
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08631
HCK_HUMAN
Homo sapiens
Tyrosine-protein kinase HCK

PDB Structure

PDB 2OI3
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution Structure of a Hck SH3 Domain Ligand Complex Reveals Novel Interaction Modes
Schmidt, H., Hoffmann, S., Tran, T., Stoldt, M., Stangler, T., Wiesehan, K., Willbold, D.
J.Mol.Biol.