CATH Domain 2nzlA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	hydroxyacid oxidase 2

Enzyme Information

1.1.3.15

(S)-2-hydroxy-acid oxidase.

based on mapping to UniProt Q9UJM8

(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).

-!- Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. -!- The rat isoenzyme B also acts as EC 1.4.3.2. -!- Formerly EC 1.1.3.1.

UniProtKB Entries (1)

Q9UJM8

HAOX1_HUMAN

Homo sapiens

Hydroxyacid oxidase 1

PDB Structure

PDB	2NZL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human hydroxyacid oxidase 1 Ugochukwu, E., Kavanagh, K., Pilka, E., Berridge, G., Debreczeni, J.E., Papagrigoriou, E., Turnbull, A., Niesen, F., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U. To be Published