CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family

Enzyme Information

1.20.4.1
Arsenate reductase (glutaredoxin).
based on mapping to UniProt P74313
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.
3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P74313
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P74313
ARSC_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Glutaredoxin arsenate reductase

PDB Structure

PDB 2MYT
External Links
Method SOLUTION NMR
Organism
Primary Citation
A Hybrid Mechanism for the Synechocystis Arsenate Reductase Revealed by Structural Snapshots during Arsenate Reduction.
Hu, C., Yu, C., Liu, Y., Hou, X., Liu, X., Hu, Y., Jin, C.
J.Biol.Chem.