CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family Low molecular weight protein-tyrosine-phosphatase

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P9WIA1
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P9WIA1
PTPA_MYCTU
Mycobacterium tuberculosis H37Rv
Probable low molecular weight protein-tyrosine-phosphatase

PDB Structure

PDB 2LUO
External Links
Method SOLUTION NMR
Organism
Primary Citation
The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development.
Stehle, T., Sreeramulu, S., Lohr, F., Richter, C., Saxena, K., Jonker, H.R., Schwalbe, H.
J.Biol.Chem.