CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Triosephosphate isomerase

Enzyme Information

5.3.1.1
Triose-phosphate isomerase.
based on mapping to UniProt P60174
D-glyceraldehyde 3-phosphate = glycerone phosphate.
4.2.3.3
Methylglyoxal synthase.
based on mapping to UniProt P60174
Glycerone phosphate = methylglyoxal + phosphate.
-!- Does not act on D-glyceraldehyde 3-phosphate. -!- Formerly EC 4.2.99.11.

UniProtKB Entries (1)

P60174
TPIS_HUMAN
Homo sapiens
Triosephosphate isomerase

PDB Structure

PDB 2JK2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Human Triosephosphate Isomerase Deficiency: Mutation E104D is Related to Alterations of a Conserved Water Network at the Dimer Interface.
Rodriguez-Almazan, C., Arreola, R., Rodriguez-Larrea, D., Aguirre-Lopez, B., De Gomez-Puyou, M.T., Perez-Montfort, R., Costas, M., Gomez-Puyou, A., Torres-Larios, A.
J.Biol.Chem.