CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family UDP-N-acetylmuramoylalanine--D-glutamate ligase

Enzyme Information

6.3.2.9
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
based on mapping to UniProt P14900
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.
-!- Involved in the synthesis of a cell-wall peptide in bacteria.

UniProtKB Entries (1)

P14900
MURD_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoylalanine--D-glutamate ligase

PDB Structure

PDB 2JFG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase.
Kotnik, M., Humljan, J., Contreras-Martel, C., Oblak, M., Kristan, K., Herve, M., Blanot, D., Urleb, U., Gobec, S., Dessen, A., Solmajer, T.
J. Mol. Biol.